DGIdb - DYPHYLLINE Drug Record

DYPHYLLINE chembl:CHEMBL1752 Approved

Alternate Names:

GLYPHYLLINE
LUFYLLIN
DIPROPHYLLINE
DILOR-400
DILOR
DYPHYLLINE
NEOTHYLLINE
(+-)-7-(2,3-DIHYDROXYPROPYL)THEOPHYLLINE
(+-)-DIPROPHYLLINE
7-(BETA,GAMMA-DIHYDROXYPROPYL)THEOPHYLLINE
(1,2-DIHYDROXY-3-PROPYL)THIOPHYLLIN
7-(Β,Γ-DIHYDROXYPROPYL)THEOPHYLLINE
1,3-DIMETHYL-7-(2,3-DIHYDROXYPROPYL)XANTHINE
DILOR®
7-(2,3-DIHYDROXYPROPYL)-1,3-DIMETHYLXANTHINE
DIHYDROXYPROPYL THEOPYLIN
(±)-DIPROPHYLLINE
(±)-DYPHYLLINE
(+-)-DYPHYLLINE
7-(2,3-DIHYDROXYPROPYL)THEOPHYLLINE
7-(2,3-DIHYDROXYPROPYL)-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE
DIPROPHYLLINUM
DIPROFILINA
chembl:CHEMBL1752
pubchem.compound:3182
rxcui:3714
drugbank:00651
chemidplus:479-18-5

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Bronchodilator Agents
Drug Class	bronchodilator agents
Drug Class	vasodilator agents
Year of Approval	approved before 1982

(1 More Sources)

Publications:

Iancu et al., 1979, Trials with xanthine derivatives in systemic treatment of psoriasis., Dermatologica
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

DYPHYLLINE PDE7B

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423

Sources:
TdgClinicalTrial TEND
DYPHYLLINE PDE7A

Interaction Score: 7.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
DYPHYLLINE PDE4C

Interaction Score: 4.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Novel drug target Established target

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND
DYPHYLLINE PDE4A

Interaction Score: 2.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 11752352 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DYPHYLLINE PDE4B

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND
DYPHYLLINE PDE4D

Interaction Score: 1.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND
DYPHYLLINE PDE3A

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

TEND: DYPHYLLINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval approved before 1982

Drug Class vasodilator agents

Drug Class bronchodilator agents

Publications:
TdgClinicalTrial: DYPHYLLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Bronchodilator Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
TTD: Dyphylline
- Version: 2020.06.01
Alternate Names:

D02PWM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1752
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1752
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Phosphodiesterase 4 inhibitor

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 3A inhibitor

DYPHYLLINE Drug Record

DYPHYLLINE chembl:CHEMBL1752 Approved

Alternate Names:

Drug Info:

Publications:

DYPHYLLINE PDE7B

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17139284 17016423

Sources: TdgClinicalTrial TEND

DYPHYLLINE PDE7A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

DYPHYLLINE PDE4C

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 4 inhibitor Novel drug target Established target

PMIDs: 225216 17016423 17139284 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND

DYPHYLLINE PDE4A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 225216 17016423 17139284 11752352 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

DYPHYLLINE PDE4B

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 225216 17016423 17139284 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND

DYPHYLLINE PDE4D

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 17016423 17139284 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND

DYPHYLLINE PDE3A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs: None found

Sources: ChemblInteractions

TEND: DYPHYLLINE

Alternate Names:

Drug Info: Year of Approval approved before 1982 Drug Class vasodilator agents Drug Class bronchodilator agents

Publications:

TdgClinicalTrial: DYPHYLLINE

Alternate Names:

Drug Info: Drug Indications Bronchodilator Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

TTD: Dyphylline

Alternate Names: D02PWM TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1752

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1752

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Novel drug target Established target

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 11752352 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
225216 17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Drug Info:

Year of Approval approved before 1982

Drug Class vasodilator agents

Drug Class bronchodilator agents

Drug Info:

Drug Indications Bronchodilator Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

D02PWM TTD Drug ID