DGIdb - APREMILAST Drug Record

APREMILAST chembl:CHEMBL514800 ApprovedImmunotherapy

Alternate Names:

CC-10004
APREMILAST
OTEZLA
CC10004
OTEZLA®
N-{2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULFONYL)ETHYL]-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL}ACETAMIDE
APREMILASTUM
CC 10004
APRÉMILAST
rxcui:1492727
chembl:CHEMBL514800
drugbank:05676
chemidplus:608141-41-9
pubchem.compound:11561674

Drug Info:

FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	antiinflammatory agent, DMARD, antipsoriatic

(0 More Sources)

Publications:

Bäumer et al., 2007, Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis., Inflamm Allergy Drug Targets
Abdulrahim et al., 2015, Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis., Expert Opin Pharmacother
Afra TP et al., 2019, Apremilast in Psoriasis and Beyond: Big Hopes on a Small Molecule., Indian Dermatol Online J

APREMILAST PDE4A

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name apremilast, CC-10004

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487 30775293

Sources:
TdgClinicalTrial ChemblInteractions TTD
APREMILAST PDE4B

Interaction Score: 1.29

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name apremilast, CC-10004

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487

Sources:
TdgClinicalTrial ChemblInteractions
APREMILAST PDE4D

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17352685 25864487

Sources:
ChemblInteractions
APREMILAST PDE4C

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APREMILAST CDK6

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
APREMILAST CDK4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TdgClinicalTrial: APREMILAST
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent, DMARD, antipsoriatic

Drug Class Small molecule

FDA Approval not approved

Publications:
TTD: Apremilast
- Version: 2020.06.01
Alternate Names:

D07ESC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL514800
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL514800
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	apremilast, CC-10004
Mechanism of Interaction	Phosphodiesterase 4 inhibitor

Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Direct Interaction	yes

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

APREMILAST Drug Record

APREMILAST chembl:CHEMBL514800 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

APREMILAST PDE4A

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name apremilast, CC-10004 Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 17352685 25864487 30775293

Sources: TdgClinicalTrial ChemblInteractions TTD

APREMILAST PDE4B

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name apremilast, CC-10004 Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 17352685 25864487

Sources: TdgClinicalTrial ChemblInteractions

APREMILAST PDE4D

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 17352685 25864487

Sources: ChemblInteractions

APREMILAST PDE4C

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

APREMILAST CDK6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

APREMILAST CDK4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TdgClinicalTrial: APREMILAST

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent, DMARD, antipsoriatic Drug Class Small molecule FDA Approval not approved

Publications:

TTD: Apremilast

Alternate Names: D07ESC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL514800

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL514800

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name apremilast, CC-10004

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487 30775293

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name apremilast, CC-10004

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17352685 25864487

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17352685 25864487

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Drug Info:

Drug Indications antiinflammatory agent, DMARD, antipsoriatic

Drug Class Small molecule

FDA Approval not approved

Alternate Names:

D07ESC TTD Drug ID